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NOVA | Memory Hackers

Last Updated by WMHT Web Editor on

Watch Wednesday, February 10 at 9pm and Sunday, February 14, 2016 at 11am on WMHT TV

Memory is the key to our identity. It’s the glue that binds our mental lives. Without it, we’d be prisoners of the present, unable to use the lessons of the past to change our future. From our first kiss to where we put our keys, memory represents who we are, how we learn and how we navigate the world. But how does it actually work? In MEMORY HACKERS, NOVA explores the cutting edge frontiers of cognitive science and molecular biology, where neuroscientists are probing our brains to unlock the secrets of human memory. The new one-hour documentary, a production of WGBH Boston, examines how memories are formed, what encompasses the act of remembering and the new technologies being used to implant, edit and even erase memories—a process that could delete our worst fears and, one day, may help us to re-write our past with the flip of a switch.

In the last 20 years, a wealth of new imaging tools—from PET scanners and TMS to fMRI—have enabled a generation of explorers to chart memory in the human brain.  For the first time, neuroscientists are uncovering the precise mechanisms of memory at the molecular level and have uncovered a provocative and alarming idea. For much of human history, memory has been seen as a tape recorder that faithfully registers information and replays it intact. Today, however, mounting evidence suggests that memory is far more malleable, constantly changing over time. It is always being written and rewritten, not just by us, but by others. Any time we recall an old memory, we essentially disrupt it. And the idea that even the simple act of remembering could make our memories vulnerable to change has transformed our entire understanding of memory.

“Memory is hugely important because it helps us understand ourselves and our lives and makes us who we are. But your memory is not as accurate as you think and far more changeable than you know,” said Paula S. Apsell, Senior Executive Producer for NOVA. “This absorbing new NOVA film looks at one of the biggest mysteries in science and captivates viewers as it looks at stories of the latest breakthroughs in human memory and the implications of manipulating human memory.”

In MEMORY HACKERS, NOVA takes viewers on a journey to try to discover exactly what memory is, how a memory is formed in the brain and how science has transformed our understanding of memory. The documentary dissects what happens in our brains each time we recollect a past experience and explores how the act of recalling a memory makes it vulnerable to change. A handful of experts are already using the malleability of memory to treat a variety of human disorders. Although the research is in its infancy, early results have been promising. This leads researchers to question whether our memories are more modifiable than we think, and, if we can already change them, will we be able to turn memories on and off one day, at the push of a button? The film highlights the latest in optogenetics, a revolutionary technique allowing researchers to map a specific memory and manipulate it with lasers. This could be one of the most important new developments in memory research, as it suggests a level and precision of control over memory that scientists have never before seen.

NOVA travels around the globe to meet the scientists working at the forefront of memory research and introduces viewers to the remarkable individuals whose exceptional memories and unique abilities are helping to unlock the secrets of memory. NOVA cameras capture firsthand as researchers test patients trying new reconsolidation therapies to try to overcome extreme fears, and more. Among the most notable memory hacking studies and experiments and fascinating stories explored in the film are the following:

 

  • Neuropsychologist Brenda Milner gives a candid interview about her early strides in the field with Patient Zero in the study of memory. Her groundbreaking work in the 1950s with “H.M.,” a man who was unable to form new memories following a surgery to remove part of his hippocampus, contributed tremendously to what we now know about the science of memory and paved the way for many researchers.

 

  • Karim Nader is a neuroscientist who is working to understand what neurobiological processes are involved in acquiring, storing and recalling memories, especially relating to fear, to treat anxiety disorders. Nader designed a simple experiment that immediately resulted in a remarkable breakthrough. Rather than each memory being like a book filed in a library archive, it appears to be more like a computer file that can be modified. His astonishing findings revealed that every time a memory is recalled, it is vulnerable to alteration, a notion that spurred hundreds of subsequent studies and may have inspired the film Eternal Sunshine of the Spotless Mind.

 

  • In Amsterdam, NOVA viewers meet experimental clinical psychologist Merel Kindt, who is working with people suffering from phobias and anxiety disorders. Kindt has developed a treatment based on Nader’s findings to abate the life-long fears of patients by administering a common blood-pressure medication, which works by blocking the action of adrenaline in the amygdala—the fear center of the brain. It’s not a “forget pill.” The original fear memory must be reactivated for it to work. NOVA viewers will see firsthand highly nervous spider-phobes vanquish their fears and calmly pet a big hairy tarantula after undergoing a treatment that destabilizes memories and then interferes with the restabilization of the original fear memory. Kindt is now among a handful of scientists using reconsolidation to treat a variety of human disorders, from drug addiction to post-traumatic stress disorder. 

 

  • NOVA viewers will also meet Jake Hausler, a 12-year-old boy who is the youngest person ever discovered with HSAM (Highly Superior Autobiographical Memory), and will see his unique ability to remember incredible details from almost every day of his life since age eight. Researchers at Washington University—including Dr. Nico Dosenbach, pediatric neurologist and systems neuroscientist at Washington University School of Medicine, and Henry L. “Roddy” Roediger and Kathleen McDermott, professors in the Psychology Department and part of the Memory Lab, are mapping Jake’s brain with new imaging technologies to uncover what makes his memory so powerful and to see if he holds the key to understanding our memory. 

 

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